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5 Biggest Games of NFL Week 2 (2023)

NFL Sunday is just a day away and we have some great games on tap. Before you settle in on your couch let’s preview some of the biggest matchups of the NFL week 2 slate.


Kansas City Chiefs (-3.5) @ Jacksonville Jaguars (1 PM EST on CBS)

The best game of the NFL week 2 schedule is when the Chiefs go on the road to take on the Jaguars. It was a disappointing opening game for Kansas City as they struggled against the Detroit Lions at home.

Quarterback Patrick Mahomes put up rather pedestrian numbers in week 1 but he was without Travis Kelce. Kelce and stud defensive tackle Chris Jones are set to return for the Chiefs in this one. Jones will be needed to help stop the rushing attack of Jacksonville led by Travis Etienne Jr. and rookie Tank Bigsby. Etienne and Bigsby each found the end zone in week 1 against the Colts.

On the outside, Calvin Ridley made a splash in his debut for the Jaguars. Ridley did not look rusty after his 1 year suspension as he hauled in 8 receptions for 101 yards and a touchdown. Ridley will be a challenge for the Chiefs secondary all game long.

Baltimore Ravens (+3) @ Cincinnati Bengals (1 PM EST on CBS)

Cincinnati would very much like to burn the tape of their week 1 performance against the rival Browns. Joe Burrow and the Bengals offense could never find a rhythm as he was held to under 100 yards passing. It was the first time in his career that Burrow was held under the 100-yard passing mark. Burrow will look to get back on track versus the rival Ravens at home.

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Meanwhile, the Ravens are coming off a dominating performance against the Houston Texans. Baltimore may have found its next star in rookie Zay Flowers. Flowers looked electric in his debut as he had 87 yards from scrimmage in week 1 including 9 receptions. Lamar Jackson and the Ravens will be without J.K. Dobbins who is now out for the season. Expect another classic AFC North battle in this one.

Seattle Seahawks (+4.5) @ Detroit Lions (1 PM EST on FOX)

Jared Goff and the Lions looked like an NFC contender in their week 1 win at Kansas City. Their defense which struggled all last season looked completely different in the opener. If they can get this type of performance consistently from their defense the Lions will be a threat come playoff time.

Seattle on the other hand looked lackluster as they were beat at home in week 1 by the Rams. Geno Smith who was the Comeback Player of the Year in 2022 struggled with a Rams defense that lacks playmakers. It was troubling to see for a Seahawks team that was set to take the next step this year. Look for this one to be another high-scoring affair. The Seahawks won 48-45 when the two teams met last season.

San Francisco 49ers (-7.5) @ Los Angeles Rams (4:05 PM EST on FOX)

Before the season started this looked to be an easy win for the 49ers. Now they may have more of a battle on their hands when they visit LA. This game will be a classic example of whether week 1 was a fluke or not. If the Rams keep it close many will start to give them respect. The problem is they will be dealing with the elite 49ers defense who will put pressure on Matthew Stafford all day long.

Rams rookie wide receiver Puka Nacua was the story of week 1 as he seemingly came out of nowhere. The Rams will need a repeat performance from Nacua who hauled in 10 receptions for 119 yards in his debut.

Washington Commanders (+3.5) @ Denver Broncos (4:25 PM EST on CBS)

Washington is looking to start 2-0 when they travel to the Mile High City on Sunday afternoon. The Commanders looked a bit shaky in their week 1 win against the Cardinals. Washington’s defense was dominant but the offense struggled at times. Quarterback Sam Howell had two costly turnovers but showed poised in leading Washington to a come-from-behind victory. Howell will need to be mistake-free on the road in Denver for Washington to have a chance.

The Broncos will be getting one of their best weapons back in Jerry Jeudy on Sunday. This is exactly what Russell Wilson and this offense needed as they look to bounce back from their week 1 loss. Wilson did have 2 touchdowns in the opener but the offense lacked explosiveness. They will need big plays to be able to beat the stingy Washington defense.

Written by
Justin Fuhr

Justin is the Owner of Pro Football Mania. He is an NFL and fantasy football fanatic who enjoys analyzing data and analytics in sports.

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