PFM NFL Injury Tracker
The 2026 San Francisco 49ers injury report currently has 16 players still being tracked. The latest San Francisco 49ers injury update is Kyle Juszczyk, currently listed as Injured.
Last updated:
Latest verified practice participation and game designations for this matchup.
Week 5 · at Seattle Seahawks · Oct 11
No verified practice or game designations are listed yet for this matchup.
hyperextended knee
Marques SigleS Injuredhigh ankle sprain
Mike EvansWR Injuredrib strain
Nick BosaDE Injuredknee/calf
Dre GreenlawLB Injuredquadriceps
Mykel WilliamsDL Monitoringknee
James Thompson Jr.DL Injuredhigh ankle sprain
Demarcus RobinsonWR Injuredhigh ankle sprain
De'Zhaun StriblingWR IRdeltoid ankle sprain
Jake TongesTE IRknee
Alfred CollinsDT IRtorn patellar tendon
Sam OkuayinonuDE IRFoot
Isaac GuerendoRB Injuredpectoral
Christian KirkWR IRInjury update
Austen PleasantsOL IRInjury update
Victor DimukejeDL IRInjury update
San Francisco loses the fullback who helps tie together its motion-heavy run and play-action packages. The 49ers can cover his snaps with tight ends, but Juszczyk's versatility lets Kyle Shanahan move between formations without changing personnel, and that flexibility is harder to replace.
San Francisco has to change its safety rotation for multiple weeks, with Malik Mustapha moving into Sigle's role. That adds another moving piece to a defense already managing injuries across the front and secondary.
Evans remaining out of practice keeps San Francisco's boundary receiving group without one of its primary size and downfield options, narrowing the offense's ability to attack outside the numbers.
Kyle Juszczyk hyperextended his knee against Denver and is expected to miss two to three weeks.
Marques Sigle suffered a high ankle sprain against Denver and is expected to miss multiple weeks.
Trent Williams is cleared to play against Denver.
Mike Evans did not practice Thursday for a second straight day because of his rib injury.
Nick Bosa did not practice Thursday and San Francisco listed him with knee and calf injuries.
Dre Greenlaw did not practice Thursday because of his quadriceps injury.
San Francisco opened Mykel Williams' practice window and he was limited Wednesday.
Kyle Shanahan said Trent Williams is expected to be good to go by Thursday after leaving Week 3 with a stinger.
Dre Greenlaw is dealing with a quad contusion, and San Francisco plans to manage his workload this week.
San Francisco plans to open Mykel Williams' practice window Wednesday as he works back from the right knee ACL and lateral meniscus injury that began his season on PUP.